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ACE inhibitor and spironolactone — GPhC CRA MCQ

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ModerateDrug InteractionsACE inhibitor and spironolactoneGPhC CRA

A patient taking ramipril is started on spironolactone for heart failure. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DHyperkalaemia

Both medicines can increase potassium, so monitoring and dose review are required. In this vignette, "Hyperkalaemia" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF