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Methotrexate folic acid — GPhC CRA MCQ

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ModeratePatient Counselling and Pharmaceutical CareMethotrexate folic acidGPhC CRA

A patient taking weekly methotrexate asks why folic acid is prescribed on a different day. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Take folic acid as prescribed to reduce methotrexate adverse effects

Folic acid reduces some methotrexate adverse effects and should be taken according to the regimen. In this vignette, "Take folic acid as prescribed to reduce methotrexate adverse effects" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS; GPhC Standards