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Colchicine diarrhoea — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsColchicine diarrhoeaGPhC CRA

A patient taking colchicine for gout develops diarrhoea and abdominal cramps. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Stop colchicine and seek medical advice if symptoms are significant

Gastrointestinal symptoms may indicate colchicine toxicity and dose interruption may be required. In this vignette, "Stop colchicine and seek medical advice if symptoms are significant" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS