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Macrolide and colchicine — GPhC CRA MCQ

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ModerateDrug InteractionsMacrolide and colchicineGPhC CRA

A patient taking colchicine for gout is prescribed clarithromycin. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Increased risk of colchicine toxicity

Clarithromycin can raise colchicine exposure and toxicity risk. In this vignette, "Increased risk of colchicine toxicity" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF