Macrolide and statin — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyInfectionsMacrolide and statinGPhC CRA

A patient taking simvastatin is prescribed clarithromycin for chest infection. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Increased risk of statin toxicity

Clarithromycin can raise simvastatin exposure and increase myopathy risk. In this vignette, "Increased risk of statin toxicity" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS