Clopidogrel and omeprazole — GPhC CRA MCQ
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Correct answer: A — Reduced clopidogrel activation
Omeprazole can inhibit CYP2C19 and reduce clopidogrel activation. In this vignette, "Reduced clopidogrel activation" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.
Reference: BNF