Neuropathic pain renal impairment — GPhC CRA MCQ

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ModerateCNS TherapeuticsNeuropathic pain renal impairmentGPhC CRA

A patient with neuropathic pain and reduced renal function cannot tolerate amitriptyline. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Renally adjusted gabapentin

Gabapentin can be used for neuropathic pain but requires dose adjustment in renal impairment. In this vignette, "Renally adjusted gabapentin" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS