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Valproate pregnancy prevention — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and SafetyValproate pregnancy preventionGPhC CRA

A woman of childbearing potential taking valproate asks for repeat supply and there is no evidence of current pregnancy prevention arrangements. What is the most appropriate action?

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Correct answer: C — Pause and urgently clarify pregnancy prevention and specialist review requirements

Valproate has major teratogenic risk and is subject to strict pregnancy prevention requirements. In this vignette, "Pause and urgently clarify pregnancy prevention and specialist review requirements" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; MHRA Drug Safety Update