PPI and clopidogrel — GPhC CRA MCQ
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Correct answer: D — Reduced clopidogrel activation
Omeprazole can inhibit CYP2C19 and may reduce clopidogrel activation; an alternative PPI may be preferred. In this vignette, "Reduced clopidogrel activation" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.
Reference: BNF; NICE CKS