Depression with insomnia — GPhC CRA MCQ

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ModerateCNS TherapeuticsDepression with insomniaGPhC CRA

A patient with depression has troublesome insomnia and poor appetite. They had nausea with sertraline. What is the most appropriate alternative?

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Correct answer: A — Mirtazapine

Mirtazapine may be useful where insomnia and poor appetite are prominent, subject to clinical suitability. In this vignette, "Mirtazapine" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS