SSRI and tramadol — GPhC CRA MCQ

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EasyCNS TherapeuticsSSRI and tramadolGPhC CRA

A patient taking sertraline is prescribed tramadol for back pain after an urgent care visit. What is the most important interaction to flag?

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Correct answer: A — Increased risk of serotonin toxicity

Tramadol has serotonergic activity and can increase serotonin toxicity risk with SSRIs. In this vignette, "Increased risk of serotonin toxicity" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS