Methotrexate and trimethoprim — GPhC CRA MCQ
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Correct answer: B — Increased risk of bone marrow suppression
Trimethoprim can add antifolate effects and increase methotrexate toxicity risk. In this vignette, "Increased risk of bone marrow suppression" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.
Reference: BNF; NICE CKS