Metformin intolerance — GPhC CRA MCQ

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EasyEndocrine TherapeuticsMetformin intoleranceGPhC CRA

A patient has diarrhoea after starting immediate-release metformin despite taking it with meals. What is the most appropriate alternative?

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Correct answer: D — Metformin modified-release

Modified-release metformin may improve gastrointestinal tolerability. In this vignette, "Metformin modified-release" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS