skip to main content

Valproate dispensing safety — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardAdverse Drug Reactions and Drug SafetyValproate dispensing safetyGPhC CRA

A 20-year-old woman taking valproate for bipolar disorder collects a repeat prescription. She says she is not using contraception and has missed her period. She has not seen a specialist recently. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Refer urgently to the prescriber or specialist and discuss pregnancy testing and risk

Valproate is associated with major teratogenic and neurodevelopmental risks. Possible pregnancy and absence of contraception require urgent clinical review, but abrupt stopping may destabilise epilepsy or bipolar disorder and should be specialist-led. The pharmacist should ensure warning materials and safeguarding advice are addressed.

Reference: BNF; MHRA Drug Safety Update