Methotrexate toxicity counselling — GPhC CRA MCQ
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Correct answer: A — Mouth ulcers, sore throat, unexplained bruising or new breathlessness
Mouth ulceration and sore throat can precede severe marrow toxicity, bruising can indicate cytopenia and new breathlessness can signal pneumonitis or infection. These warrant prompt assessment even if recent monitoring was normal; weekly dosing and interaction checks remain essential.
Reference: BNF: methotrexate: https://bnf.nice.org.uk/drugs/methotrexate/