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Naloxone and opioid safety — GPhC CRA MCQ

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ModerateCNS TherapeuticsNaloxone and opioid safetyGPhC CRA

A patient collects oxycodone modified-release for chronic non-cancer pain after a recent dose increase. His partner says he has been very sleepy and occasionally difficult to rouse. He also takes diazepam at night. What is the most appropriate action?

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Correct answer: E — Advise urgent clinical review because opioid toxicity risk is possible

Excessive sedation and difficulty rousing may indicate opioid toxicity, especially after dose escalation and with benzodiazepine co-use. This can progress to respiratory depression. Modified-release tablets must not be crushed, and urgent prescriber or emergency advice is needed depending on severity.

Reference: BNF; NICE CKS