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Uncomplicated UTI renal function — GPhC CRA MCQ

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ModerateInfectionsUncomplicated UTI renal functionGPhC CRA

A 67-year-old woman is prescribed nitrofurantoin 100 mg modified-release twice daily for lower UTI. Her recent eGFR is 27 mL/min/1.73 m2. She has dysuria but no fever or flank pain. What is the most appropriate alternative?

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Correct answer: C — Contact the prescriber to select a more suitable antibiotic

Nitrofurantoin is ineffective and unsuitable in significant renal impairment because urinary concentrations may be inadequate and toxicity risk rises. An eGFR of 27 mL/min/1.73 m2 makes the prescription inappropriate for routine use. The prescriber should choose an alternative based on local guidance and patient factors.

Reference: NICE CKS; BNF