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Denosumab calcium monitoring — GPhC CRA MCQ

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ModerateMusculoskeletal TherapeuticsDenosumab calcium monitoringGPhC CRA

A 73-year-old woman is due to start denosumab for osteoporosis. She has chronic kidney disease stage 4 and low vitamin D. The clinic asks what should be checked before the first injection. What monitoring is required?

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Correct answer: D — Corrected calcium and vitamin D status

Denosumab can cause hypocalcaemia, with higher risk in significant renal impairment and vitamin D deficiency. Corrected calcium and vitamin D status should be assessed and corrected before treatment where needed. Ongoing calcium monitoring may be required depending on risk.

Reference: BNF