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PPI and clopidogrel — GPhC CRA MCQ

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ModerateGastro-intestinal TherapeuticsPPI and clopidogrelGPhC CRA

A man taking clopidogrel asks to buy omeprazole for recurrent heartburn. He has had no weight loss, dysphagia or vomiting. The pharmacy record shows previous lansoprazole use. What is the most important interaction to flag?

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Correct answer: C — Omeprazole can reduce clopidogrel activation

Omeprazole and esomeprazole can inhibit CYP2C19 and reduce conversion of clopidogrel to its active metabolite. If a PPI is needed, another option such as lansoprazole may be preferred depending on local guidance. Alarm symptoms would require referral.

Reference: BNF