skip to main content

Lamotrigine rash — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCNS TherapeuticsLamotrigine rashGPhC CRA

A 22-year-old woman started lamotrigine for epilepsy 12 days ago. She presents with a widespread rash and mouth soreness. She has no breathing difficulty but feels unwell. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Advise urgent medical assessment and do not continue doses without review

Lamotrigine is associated with serious skin reactions, including Stevens-Johnson syndrome, particularly early in treatment. Rash with mucosal symptoms and systemic upset needs urgent assessment. Continuing treatment without review could be dangerous.

Reference: BNF