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Clozapine myocarditis — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyClozapine myocarditisGPhC CRA

A 30-year-old man started clozapine three weeks ago. He reports chest pain, fever and shortness of breath. He asks whether this is a common cold. What is the most appropriate action?

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Correct answer: D — Advise urgent medical assessment for possible clozapine myocarditis or infection

Clozapine can rarely cause myocarditis, particularly early in treatment, and can also cause serious blood disorders. Chest pain, fever and breathlessness require urgent medical assessment. The clozapine team or prescriber should be contacted promptly.

Reference: BNF; clozapine monitoring guidance