skip to main content

SSRI and NSAID bleeding — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A 50-year-old man taking fluoxetine asks to buy ibuprofen for shoulder pain. He has a history of gastritis and occasionally takes aspirin bought from a supermarket. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Fluoxetine with NSAIDs increases gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs add gastrointestinal bleeding risk. Previous gastritis and aspirin use increase concern. The pharmacist should consider safer analgesia and referral if pain needs NSAID treatment or gastroprotection.

Reference: BNF