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MAOI interaction — GPhC CRA MCQ

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ModerateCNS TherapeuticsMAOI interactionGPhC CRA

A 61-year-old man taking phenelzine asks to buy pseudoephedrine for nasal congestion. He has hypertension and says he used decongestants before starting the antidepressant. What is the most important interaction to flag?

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Correct answer: E — Pseudoephedrine with phenelzine may precipitate a hypertensive reaction

Monoamine oxidase inhibitors can interact dangerously with sympathomimetics such as pseudoephedrine. The combination may cause severe hypertension and should be avoided. Safer symptomatic options should be discussed, considering his hypertension and current medicines.

Reference: BNF