skip to main content

Azole and sulfonylurea — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateDrug InteractionsAzole and sulfonylureaGPhC CRA

A 69-year-old man taking gliclazide is prescribed fluconazole for oral candidiasis. He lives alone and has had previous hypoglycaemia. His renal function is normal. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Fluconazole can increase sulfonylurea effect and hypoglycaemia risk

Fluconazole can inhibit metabolism of some sulfonylureas and increase hypoglycaemia risk. The patient should be counselled on symptoms and management of hypoglycaemia, and the prescriber may need to consider monitoring or alternatives. Living alone increases the safety concern.

Reference: BNF