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Metformin gastrointestinal intolerance — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsMetformin gastrointestinal intoleranceGPhC CRA

A 60-year-old woman started metformin immediate-release 500 mg twice daily two weeks ago. She reports nausea and diarrhoea but wants to continue diabetes treatment if possible. Her renal function is normal. What is the most appropriate alternative?

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Correct answer: C — Review titration or modified-release metformin

Metformin commonly causes gastrointestinal adverse effects when started or increased. Taking with food, slower titration or a modified-release formulation can improve tolerability. Changes to prescription therapy should be discussed with the prescriber.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment