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IBD flare steroid rectal therapy — GPhC CRA MCQ

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ModerateGastro-intestinal TherapeuticsIBD flare steroid rectal therapyGPhC CRA

A 29-year-old man with known ulcerative proctitis has rectal bleeding and urgency. He is prescribed mesalazine suppositories and asks why oral loperamide is not the main treatment. What would you advise the patient?

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Correct answer: C — Rectal anti-inflammatory treatment targets distal inflammation causing symptoms

Ulcerative proctitis symptoms arise from distal mucosal inflammation. Rectal mesalazine can deliver high local drug concentrations to the affected area. Loperamide does not treat inflammation and may be unsuitable in significant active colitis.

Reference: BNF; NICE CKS