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Nitrofurantoin renal contraindication — GPhC CRA MCQ

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EasyRenal and Hepatic ImpairmentNitrofurantoin renal contraindicationGPhC CRA

An 84-year-old woman with creatinine clearance 24 mL/min is prescribed nitrofurantoin for suspected lower UTI. She has no fever or flank pain. The pharmacy has a recent renal function result. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Contact the prescriber because nitrofurantoin is unsuitable at this renal function

Nitrofurantoin depends on renal secretion into urine and is unsuitable in significant renal impairment. Low renal function may reduce efficacy and increase adverse effects. The prescriber should choose an alternative based on culture, local guidance and patient factors.

Reference: BNF; NICE CKS