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Ondansetron constipation risk — GPhC CRA MCQ

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ModerateGastro-intestinal TherapeuticsOndansetron constipation riskGPhC CRA

A patient receiving ondansetron after chemotherapy asks why constipation has worsened despite eating normally. He has no abdominal distension, vomiting or severe pain. He is also taking codeine. What would you advise the patient?

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Correct answer: E — Ondansetron and codeine can both contribute to constipation; discuss laxative management

Ondansetron commonly causes constipation, and codeine can compound this effect. Bowel symptoms should be assessed for red flags, especially in oncology patients. Laxative treatment and review of constipating medicines may be needed in liaison with the care team.

Reference: BNF