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Clozapine infection safety — GPhC CRA MCQ

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ModerateCNS TherapeuticsClozapine infection safetyGPhC CRA

A 42-year-old man taking clozapine presents with sore throat, fever and mouth ulcers. He asks to buy paracetamol and says his next blood test is due in two weeks. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Advise urgent same-day contact with the clozapine monitoring service or prescriber

Clozapine can cause agranulocytosis and infection symptoms may be a warning sign. Fever, sore throat or mouth ulcers require urgent assessment and blood count advice through the clozapine monitoring system or prescriber. Symptomatic treatment alone is not adequate.

Reference: BNF; MHRA advice