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Antibiotic renal dosing — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentAntibiotic renal dosingGPhC CRA

A 79-year-old woman with creatinine clearance 19 mL/min is prescribed co-amoxiclav 625 mg three times daily for an infected leg ulcer. She is frail and weighs 48 kg. What is the most appropriate action?

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Correct answer: D — Check renal dose appropriateness with the prescriber before supply

Many antibiotics require dose adjustment or interval change in renal impairment. Frailty, low body weight and creatinine clearance of 19 mL/min make dose checking important. The pharmacist should clarify rather than supply an unsafe regimen.

Reference: BNF