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Linezolid and SSRI — GPhC CRA MCQ

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HardDrug InteractionsLinezolid and SSRIGPhC CRA

A hospital outpatient prescription for linezolid is presented for a patient taking sertraline 100 mg daily. The indication is resistant cellulitis. The patient says nobody mentioned stopping sertraline. What is the most important interaction to flag?

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Correct answer: B — Linezolid with sertraline can increase serotonin syndrome risk

Linezolid has monoamine oxidase inhibiting properties and can interact with serotonergic medicines. Serotonin syndrome is a serious potential adverse effect. The prescriber should be contacted to confirm the plan, counselling and monitoring.

Reference: BNF