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Domperidone cardiac risk — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsDomperidone cardiac riskGPhC CRA

A 79-year-old woman requests domperidone for nausea. She has heart failure, takes amiodarone and has a history of prolonged QT interval. She is not vomiting blood and has no severe abdominal pain. What is the most appropriate action?

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Correct answer: C — Do not supply and refer for prescriber assessment

Domperidone can prolong QT interval and is contraindicated or unsuitable in patients with significant cardiac risk or QT-prolonging medicines. Amiodarone and previous QT prolongation make supply unsafe. The patient needs assessment for the cause of nausea and a safer option if treatment is required.

Reference: BNF; MHRA Drug Safety Update