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Statin myopathy — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyStatin myopathyGPhC CRA

A 67-year-old woman taking atorvastatin 80 mg daily after myocardial infarction reports new severe muscle pain and dark urine. She recently completed clarithromycin for pneumonia. What is the most appropriate action?

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Correct answer: D — Advise urgent medical assessment for possible rhabdomyolysis

Severe muscle pain with dark urine suggests possible rhabdomyolysis. Recent clarithromycin exposure increases statin toxicity risk, especially with high-dose atorvastatin. Urgent assessment, creatine kinase and renal function testing are needed.

Reference: BNF; NICE CKS