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Digoxin and verapamil — GPhC CRA MCQ

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HardDrug InteractionsDigoxin and verapamilGPhC CRA

An 81-year-old woman taking digoxin for atrial fibrillation is prescribed verapamil for rate control. She has nausea and her pulse is 50 bpm. Her renal function is reduced. What is the most important interaction to flag?

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Correct answer: A — Verapamil can increase digoxin levels and bradycardia risk

Verapamil can increase digoxin exposure and both medicines can slow atrioventricular conduction. Bradycardia and nausea are concerning for toxicity or excessive rate control. Prescriber review and possible digoxin level assessment are needed.

Reference: BNF