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PDE5 inhibitor nitrate interaction — GPhC CRA MCQ

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EasyCardiovascular TherapeuticsPDE5 inhibitor nitrate interactionGPhC CRA

A 61-year-old man prescribed isosorbide mononitrate modified-release for angina asks to buy sildenafil after seeing an advert. He has no current chest pain and takes atorvastatin. What is the most important interaction to flag?

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Correct answer: C — Sildenafil with nitrates may cause severe hypotension

Phosphodiesterase type 5 inhibitors can potentiate the hypotensive effects of nitrates. The combination can cause profound symptomatic hypotension and should be avoided. The patient should be referred to the prescriber to discuss erectile dysfunction management safely.

Reference: BNF