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Warfarin and thyroid status — GPhC CRA MCQ

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HardEndocrine TherapeuticsWarfarin and thyroid statusGPhC CRA

A patient taking warfarin starts levothyroxine after a new diagnosis of hypothyroidism. The anticoagulation clinic asks the pharmacy to flag any relevant issue during counselling. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Changing thyroid status can alter warfarin sensitivity and INR

Thyroid status can affect warfarin response, and starting levothyroxine may change anticoagulant sensitivity as the patient becomes euthyroid. INR monitoring may need closer attention during stabilisation. The patient should be counselled to keep anticoagulation appointments and report bleeding.

Reference: BNF