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Apixaban and NSAID — GPhC CRA MCQ

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EasyDrug InteractionsApixaban and NSAIDGPhC CRA

A 72-year-old woman taking apixaban for atrial fibrillation asks to buy naproxen for hip osteoarthritis. She has a previous gastric ulcer and takes no PPI. What is the most important interaction to flag?

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Correct answer: C — Naproxen with apixaban increases bleeding risk

NSAIDs increase bleeding risk when used with anticoagulants, especially in patients with previous ulcer disease. Naproxen also carries gastrointestinal risk. Safer analgesia and referral for osteoarthritis pain management should be considered.

Reference: BNF