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SJS warning with carbamazepine — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetySJS warning with carbamazepineGPhC CRA

A patient started carbamazepine for trigeminal neuralgia two weeks ago. She phones about a spreading blistering rash, fever and sore eyes. She asks whether to continue until her review. What is the most appropriate action?

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Correct answer: C — Advise emergency medical assessment for possible severe cutaneous adverse reaction

Blistering rash with fever and eye involvement may indicate Stevens-Johnson syndrome or toxic epidermal necrolysis. Carbamazepine is a recognised trigger, particularly early in treatment. Immediate medical assessment is needed and further doses should not be taken without urgent clinical advice.

Reference: BNF; MHRA Drug Safety Update