DOAC renal dose check — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCardiovascular TherapeuticsDOAC renal dose checkGPhC CRA

A patient takes patiromer at 08:00 with levothyroxine, amlodipine, clopidogrel, furosemide and warfarin. To minimise unnecessary schedule changes, which medicine specifically needs to be moved to at least 3 hours before or after patiromer?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Levothyroxine

Patiromer can bind some oral medicines and reduce their gastrointestinal absorption. The current SmPC identifies reduced bioavailability with levothyroxine and shows that separating administration by 3 hours prevents the interaction. It also reports no clinically relevant interaction requiring separation for amlodipine, clopidogrel, furosemide or warfarin. The whole medication list should still be checked when therapy changes.

Reference: Veltassa (patiromer) SmPC: https://www.medicines.org.uk/emc/product/10416/smpc