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Tadalafil and alpha-blocker — GPhC CRA MCQ

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ModerateDrug InteractionsTadalafil and alpha-blockerGPhC CRA

A 70-year-old man taking doxazosin for hypertension asks to buy tadalafil for erectile dysfunction. He reports occasional dizziness on standing. What is the most important interaction to flag?

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Correct answer: A — Tadalafil with doxazosin can increase symptomatic hypotension

Phosphodiesterase type 5 inhibitors can add to the blood-pressure-lowering effect of alpha-blockers. Existing postural dizziness increases risk of falls or syncope. The patient should be referred for assessment rather than supplied without review.

Reference: BNF