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Sildenafil and nitrates — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsSildenafil and nitratesGPhC CRA

A man using glyceryl trinitrate spray for angina asks to buy sildenafil for erectile dysfunction. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Severe hypotension from sildenafil with nitrates

This scenario assesses Sildenafil and nitrates in a UK pharmacy practice context. PDE5 inhibitors markedly potentiate nitrate vasodilation and can cause dangerous hypotension. The best answer is Severe hypotension from sildenafil with nitrates because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF; MEP