Trimethoprim methotrexate infection — GPhC CRA MCQ
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Correct answer: B — Bone marrow suppression risk
This scenario assesses Trimethoprim methotrexate infection in a UK pharmacy practice context. Trimethoprim increases antifolate toxicity risk with methotrexate and should usually be avoided. The best answer is Bone marrow suppression risk because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.
Reference: BNF