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Sertraline hyponatraemia — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetySertraline hyponatraemiaGPhC CRA

An older woman started sertraline and now has confusion, falls and nausea while taking a thiazide. What monitoring is required?

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Correct answer: A — Serum sodium and other electrolytes

This scenario assesses Sertraline hyponatraemia in a UK pharmacy practice context. SSRIs can cause hyponatraemia, especially in older people and with thiazide diuretics. The best answer is Serum sodium and other electrolytes because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF; NICE CKS