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Warfarin metronidazole — GPhC CRA MCQ

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ModerateDrug InteractionsWarfarin metronidazoleGPhC CRA

A warfarin patient with INR 2.5 last week is prescribed metronidazole for dental infection. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DDiscuss a non-interacting antibiotic choice or INR plan with the prescriber

This scenario assesses Warfarin metronidazole in a UK pharmacy practice context. Metronidazole can markedly increase anticoagulant effect, so the safest response is to involve the prescriber before supply. The best answer is Discuss a non-interacting antibiotic choice or INR plan with the prescriber because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF