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ACE inhibitor diuretic NSAID — GPhC CRA MCQ

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HardDrug InteractionsACE inhibitor diuretic NSAIDGPhC CRA

A man taking lisinopril and furosemide asks for ibuprofen after two days of vomiting. What is the most important interaction to flag?

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Correct answer: E — Acute kidney injury risk

This scenario assesses ACE inhibitor diuretic NSAID in a UK pharmacy practice context. ACE inhibitor or ARB, diuretic and NSAID exposure can reduce renal perfusion and precipitate AKI. The best answer is Acute kidney injury risk because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF