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Clarithromycin simvastatin — GPhC CRA MCQ

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ModerateDrug InteractionsClarithromycin simvastatinGPhC CRA

A patient taking simvastatin is prescribed clarithromycin. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: ADiscuss a non-interacting antibiotic choice or temporary statin plan

This scenario assesses Clarithromycin simvastatin in a UK pharmacy practice context. Clarithromycin can increase simvastatin exposure and myopathy risk, so an alternative plan should be agreed. The best answer is Discuss a non-interacting antibiotic choice or temporary statin plan because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF