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ACE inhibitor creatinine rise — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentACE inhibitor creatinine riseGPhC CRA

A man started ramipril and creatinine rises mildly from 90 to 102 micromol/L with potassium 4.8. What monitoring is required?

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Correct answer: A — Repeat renal function and potassium according to the titration plan

This scenario assesses ACE inhibitor creatinine rise in a UK pharmacy practice context. A small creatinine rise may be acceptable after ACE inhibitor initiation, but ongoing monitoring is required. The best answer is Repeat renal function and potassium according to the titration plan because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: NICE CKS; BNF