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Lamotrigine rash — GPhC CRA MCQ

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EasyCNS TherapeuticsLamotrigine rashGPhC CRA

A patient develops widespread rash and fever three weeks after starting lamotrigine. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Stop further doses pending urgent medical assessment

This scenario assesses Lamotrigine rash in a UK pharmacy practice context. Rash with systemic symptoms soon after lamotrigine initiation may indicate a serious cutaneous adverse reaction. The best answer is Stop further doses pending urgent medical assessment because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF; MHRA Drug Safety Update