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Bloody diarrhoea loperamide — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsBloody diarrhoea loperamideGPhC CRA

An adult with newly diagnosed CMV retinitis has creatinine clearance 32 mL/min and is prescribed valganciclovir induction treatment. Which tablet regimen matches the renal-dose table?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Give 450 mg once daily during the induction phase

Explanation lettering: C = shown as A · D = shown as B · E = shown as C · B = shown as D · A = shown as E

A is the full induction dose for creatinine clearance at least 60 mL/min. B corresponds to induction dosing at 40–59 mL/min. C is correct: at 25–39 mL/min, the valganciclovir tablet table specifies 450 mg once daily for induction. D is the induction interval for 10–24 mL/min. E resembles the maintenance schedule at 10–24 mL/min and would markedly underdose induction at this renal function.

Reference: Valganciclovir 450 mg tablets SmPC. https://www.medicines.org.uk/emc/product/13566/smpc