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Isotretinoin mood change — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyIsotretinoin mood changeGPhC CRA

A teenager on isotretinoin reports new low mood and withdrawal since starting therapy. What is the most appropriate action?

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Correct answer: B — Assess immediate safety and encourage urgent prescriber discussion

This scenario assesses Isotretinoin mood change in a UK pharmacy practice context. Mood changes during isotretinoin treatment should be taken seriously and reviewed promptly. The best answer is Assess immediate safety and encourage urgent prescriber discussion because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: MHRA Drug Safety Update; BNF